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Description
Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis. NEJM
It is being shown to be less tested
Studies in the pig showed GLP-1 inhibited pancreatic secretion induced by hypoglycemia (central neural stimulation) but not that due to vagal nerve stimulation (126)
These conditions are prevalent, and approved agents are often not covered by patients medical insurance

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