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A recent preliminary study by researchers in Brazil and the United States suggests that GLP-1 medications for weight loss, such as Ozempic and Wegovy, may reduce the need for emergency care among people with chronic migraine compared with those who are treated with topiramate for migraine prevention

However, women experiencing severe nausea, vomiting, or acute GI symptoms during tirzepatide initiation should discuss backup contraception methods with their provider, as pill efficacy may be temporarily compromised during periods of GI upset

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