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Short-acting GLP-1RAs (exenatide [ t 1/2 of 2.4 hours] and lixisenatide [ t 1/2 of 24 hours] administered before meals twice-daily and once-daily, respectively) exhibit intermittent GLP-1 receptor activation translating into potent deceleration of upper gastrointestinal motility, an effect which is sustained during prolonged treatment

The most common early side effects are gastrointestinal including nausea, vomiting, and diarrhoea consistent with other GLP-1-containing therapies

Wegovy: Approved for chronic weight management in adults with obesity or those who are overweight with at least one weight-related comorbidity

ACE/ARB, angiotensin converting enzyme inhibitors/angiotensin-receptor blockers Postop, Postprocedural

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