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Effects of subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: A multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial

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Treatment recommendations are individualized and based on safety, appropriateness, and clinical judgment

Daily GIP injections led to a decrease in the adipose tissue gene expression levels of pro-inflammatory cytokines, such as Il-1 beta, Il-6, TNF-alpha in wild-type mice, 60 while blood levels of adiponectin, an anti-inflammatory and insulin-sensitizing adipokine, are enhanced