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They suppressed autoimmune reactions by inhibiting the activation of self-reactive T cells that could harm the bodys tissues

doi: 10.1111/dom.14725 45 CrinAGrugniG

The full publication is available here References: Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP

For example, exendin-4 lowers very-low-density lipoprotein cholesterol (VLDL-C) and LDL-C in animal models by reducing hepatic sterol regulatory element-binding protein 2 (SREBP2) levels and cholesterol absorption (88)

UKPDS (UK Prospective Diabetes Study), a large randomized clinical study in the newly diagnosed T2D population found significant as well as persistent risk reduction in myocardial infarction (33%, p = 0.005), death from any cause (27%, p = 0.002) and diabetes-related endpoint (21%, p = 0.01) in metformin-treated individuals