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PMID: 32928579

Work closely with your GP or diabetes specialist nurse to: Follow recommended dosing : Ozempic treatment begins with 0.25 mg weekly as a starter dose (not a therapeutic dose) for 4 weeks, then typically increases to 0.5 mg and potentially to maintenance doses of 12 mg as per the SmPC and your prescriber's guidance Set realistic targets : Aim for 510% body weight reduction over 36 months as recommended by NICE, rather than aggressive goals Regular monitoring : Schedule reviews every 36 months to assess treatment response and adjust as needed Facial exercise and skincare strategies may help maintain skin tone, though evidence remains limited

When comparing tirzepatide and semaglutide as treatment options, several factors come into play: Efficacy In head-to-head clinical trials, tirzepatide has demonstrated superior efficacy in both weight loss and glycemic control compared to semaglutide

Although a prospective cohort study [110] and a recently published randomized controlled trial [105] provided robust evidence of clinical benefits deriving from the use of semaglutide in adult T1D patients, it is worth specifying that the other studies examined in the present review are retrospective observational studies, post-hoc analyses, case series and case reports, which evaluated the impact of the off-label use of semaglutide and tirzepatide in patients with T1D and LADA within a real-world context