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The significant change in FLI and not HSI in our study population, which had no signs of NASH (normal liver enzyme levels) at baseline, would reflect the predominant effect of the drug more on waist circumference, which enters the calculation of FLI alone and is more related to visceral fat, than on liver enzymes

Her other long-term medications included mirtazapine (started in February 2024) for anxiety and depression, amitriptyline (started in May 2020), and pregabalin (started in May 2021) for back pain

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Although they are well known for helping with weight loss, they also have powerful anti-inflammatory and immune-modulating effects, which is why many women with Lipedema are finding them helpful even when weight loss is not the main goal