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Urva, et al., LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept, 2022, Cell Metabolism 34, 12341247

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Lastly, in a nonhuman primate model of AD, liraglutide provides partial protection, reducing AD-related insulin receptor, synaptic, and tau pathology in specific brain regions [82]

If development started today, oral tirzepatide would likely require 6-11 years to reach FDA approval (typical pharmaceutical development timeline)