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If so, what magnitude of improvement in cardiovascular outcomes will be necessary to move the needle

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However, several GLP-1 medications can be kept at room temperature for limited periods before first use, according to their specific product information: Wegovy (semaglutide) : Unopened pens may be kept at temperatures up to 30C for up to 28 days before use Trulicity (dulaglutide) : Unopened pens may be kept at temperatures up to 30C for up to 14 days before use Ozempic, Victoza, Saxenda : Check the specific product information for allowable room temperature storage before first use When storing unopened pens in the refrigerator: Keep the pen in its original carton to protect it from light exposure, which can degrade the active ingredient Store towards the back of the refrigerator rather than in the door, where temperature fluctuations are more common Never place the pen in the freezer compartment or allow it to freeze

Safety and Side Effect Considerations When Combining Both Medications The most critical safety concern with semaglutide-phentermine combinations is cardiovascular stress

Prevention is straightforward with the right preparation