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Description
A key target is the ventromedial hypothalamus since loss of Klb expression in this brain region blocks the ability of FGF21 to reduce carbohydrate intake and sucrose preference [61]

Target: 75-80% of weight loss from fat, maximum 20% from muscle

Concurrently, an increase in adiponectin, an anti-inflammatory adipokine, was observed, suggesting a reprogramming of adipocyte secretion toward a protective phenotype
Commonly reported side effects include: Nausea or queasiness Reduced appetite Digestive changes Dry mouth Metallic or altered taste sensations These effects vary by individual, dosage, and duration of treatment
Semaglutide comparison
