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Medication choice, dosing, pharmacy selection, and treatment planning require a licensed clinician who can evaluate medical history, contraindications, monitoring needs, other medications, pregnancy plans, and current product labeling

For example, once weekly dosing of tirzepatide (a dual GIPR and GLP-1R co-agonist) has superior efficacy for weight reduction compared to the GLP-1R agonist, semaglutide

If anxiety peaks when drug levels are highest, the dose may be too high

The direct effect is often overstated in popular writing, since resting muscle burns only around 13 to 15 kcal per kilogram per day, so a few kilograms of lost muscle costs only a few dozen calories directly

Jalleh RJ, Marathe CS, Rayner CK, et al