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One possible explanation is that the anti-inflammatory and neuroimmune effects of GLP-1 receptor activation may occur at lower levels of receptor engagement than the metabolic effects (like weight loss or appetite suppression)

The binding affinity of lixisenatide to GLP-1R is fourfold higher than native GLP-1 (17)

The spectrum ranges from simple steatosis (fat accumulation without significant inflammation) to nonalcoholic steatohepatitis (NASH), which involves inflammation and hepatocyte injury that can progress to fibrosis, cirrhosis, and hepatocellular carcinoma

When given orally, semaglutide is dosed differently as absorption and delivery are different from injectable semaglutide (more on that below)

Semaglutide (Ozempic, Wegovy) targets one receptor: GLP-1