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Studies were deemed eligible for inclusion if they met the following criteria: (1) Population: adults (aged 18 years) classified as overweight or obese (BMI 25 kg/m), (2) Intervention: administration of fluoxetine, (3) Comparator: a placebo group, and (4) Outcome: reported mean and standard deviation (SD) of body mass index (BMI), BW, and/or waist circumference (WC) at both baseline and the end of the intervention