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For the subgroup analysis, the studies were classified based on if the patients from the control group received metformin or placebo
GLP-1s are generally safe, but some drugs have been withdrawn from the market due to long-term risks

Colognesi, M., Gabbia, D., Signor, A., Comai, S., Mattarei, A., Pasut, G., Folli, F., Centofanti, L., La Rosa, S., Finzi, G., Pappagallo, M., Manfredi, P., & De Martin, S

SGLT2 inhibitors and GLP-1 receptor agonists provide distinct cardiorenal protection

But the key is smart, personalized usenot blind experimentation