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Notably, nearly 50% of the retatrutide phase 2 obesity trial were men, which is higher than in phase 3 clinical trials with tirzepatide (32.5% in SURMOUNT-1 [27]) and semaglutide 2.4 mg (25.9% in STEP-1 [8])
While there is no definitively established direct mechanism by which GLP-1 receptor agonists cause fatigue, several biological pathways warrant consideration
Factors favoring insulin therapy (Toujeo) Type 1 diabetes (absolute indication)
The functions are illustrated in the Figure ( Figure 4 )
Factors such as side effect profiles, coexisting medical conditions, access, and cost must be considered