retatrutide mechanism triple agonist glp-1 gip glucagon ly3437943 vs Semaglutide: vs Single Comparison - Which Is Better? | PPW The Road towards Triple Agonists:
Description
& Klein, J

Interestingly, no preclinical studies evaluate the mechanism between DR and semaglutide, which is the only GLP-1RA to show high levels of DR in trials

Such reticence is justified

A Scoping Review

It is important to individualise the approach when switching from one GLP1RA to another, and the patient should be consulted before the switch is initiated
