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While NAION typically only impacts one eye, if a patient continues to take a GLP-1 after suffering NAION in one eye, it is possible for the patient to later develop NAION in the other eye too

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[DOI] [PubMed] [Google Scholar] 231.Xultophy 100/3.6 (insulin degludec and liraglutide injection): Prescribing information

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Large clinical trials have shown: Approximately 20% reduction in major CV events Reduced proteinuria and slower kidney function decline Improved quality of life and energy levels Additional Systemic Effects Research also suggests benefits across other domains: Sleep quality: Weight lossdriven reductions in apnea severity Neurocognitive health: Early signals of protection against dementia, though definitive evidence is still developing Together, these outcomes position GLP-1s as a unifying therapy for overlapping metabolic, cardiovascular and renal conditions