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This central 5-HT-GLP-1 interaction was further shown to enhance proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neuron activity, boosting satiety signals, and concomitantly suppress neuropeptide Y/agouti-related peptide (NPY/AgRP) neuron activity, which diminishes hunger [22]

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FGF21 is a newly discovered metabolic hormone produced in multiple tissues and secreted in the fasting state and regulates metabolic responses in the pancreas, liver and adipose tissues (95)

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