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Comorbidities such as sleep apnea, thyroid dysfunction, or polycystic ovary syndrome also modify response rates

By January 2024, monthly Medicaid spending on Wegovy alone exceeded $51 million, and by October 2024, it had grown to $192 million

These benefits include reducing neuroinflammation, improving neuronal energy homeostasis, and limiting neurodegenerative progression ( Potential mechanisms by which GLP-1RAs enhance cognition in T2DM patients include attenuation of oxidative stress, suppression of neuroinflammation, inhibition of apoptosis, reduction or prevention of A accumulation, and mitigation of tau aggregation ( These pharmacological advances have reshaped the management of metabolic diseases, improving glycemic control, weight reduction, and cardiovascular outcomes

No serious clinician disputes the numbers

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