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Further, Xavier noted that she and her colleagues did not assess possible psychiatric side effects with these drugs in the studies they reviewed, so they could not say that these GLP-1 receptor agonists were completely safe in their own findings

Medical organizations such as the Cleveland Clinic explain that GLP-1 medications like semaglutide and tirzepatide were originally developed to treat type 2 diabetes before their powerful weight-loss effects were widely recognized

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Solmaz et al., 2015)