risks of glp 1 agonists Managing Side Effects GLP-1 Receptor – Transformation Weight Control GLP-1 receptor agonists are increasingly

However, observational studies have identified potential risk-amplifying effects in specific clinical contexts

doi: 10.1016/j.mce.2020.110792 186 QinYLiTZhaoHMaoZDingCKangY

This process involves neural circuits modulated by neuropeptides, such as corticotropin-releasing factor.150 Dopamine plays a central role in mediating the immediate reinforcing effects of drugs, and dysregulation of the dopaminergic system has been proposed as a predisposing factor for chronic substance use and the maintenance of addiction.151 Dopaminergic neurons originating in the VTA project to the NAcc, amygdala, hippocampus, and prefrontal cortex, while those from the substantia nigra project to the dorsal striatum.152 The activation or disinhibition of VTA dopaminergic neurons is critical for the potentiation of alcohol, nicotine, and opioids.152 Cocaine exerts its effects by inhibits dopamine reuptake by blocking dopamine transporters, thereby increasing or prolonging synaptic dopamine concentrations.152 Other central nervous system stimulants elevate synaptic dopamine via mechanisms such as dopamine reuptake inhibition, reversal of dopamine transporter function, and promotion of dopamine release.153 However, the mechanisms by which GLP-1 receptor stimulation modulates dopaminergic function remain unclear

DPP-4 inhibitors are capable of lowering HbA1c percentage by ~0.51 unit

Cardiometabolic parameters during GLP-1 RA treatment GLP-1 RAs have also demonstrated important cardioprotective benefits that extend beyond their impact on BW loss