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Description
Although the primary outcome was cardiotoxicity rather than metabolic disease, which limits its relevance to obesity or insulin resistance, this study provided insights into the effect pathways along which Akkermansia acts

Notably, various exendin-4-based GLP-1RAs (Exenatide: 39 aa and Lixisenatide: 44 aa), and GLP-1-based GLP-1RAs (Dulaglutide: 31 aa, Liraglutide: 31 aa, Semaglutide: 31 aa, Tirzepatide: 39 aa, and Albiglutide: 60 aa) have been developed and approved by the FDA between 2005 and 2022 for the management of T2DM (Liu, 2024)

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It's confusing a temporary, adaptive response with a direct pharmacological side effect
