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Description
Most studies report the absence [[397], [398], [399]] or very restricted expression of the GLP-1 receptor in a small subset (10%) of -cells [395], and treatment of isolated rat -cells with GLP-1 enhances rather than inhibits the release of glucagon [[604], [605], [606]]

A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: a tale of bottom-up vs top-down recognition of covariates

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