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aHR: 0.57, 95% CI: 0.510.64) (Table 2, Table S3-4)

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Therefore, multi-targeting or unimolecular peptides possessing combinatorial agonism at GIPR, GLP-1R and GCGR have been extensively explored and more than a dozen peptides including two GIPR/GLP-1R dualagonists, ten GLP-1R/GCGR dualagonists and five GIPR/GLP-1R/GCGR triagonists have entered into clinical development (Fig

c , Cumulative food intake (GLP-1:GIP:Lani 10 nmol/kg and 50 nmol/kg, n = 6
