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(2025) confirmed these patterns across the drug class: GLP-1 RAs significantly reduce lean mass (mean difference: 0.86 kg ), with the most potent agents for weight losssemaglutide 2.4 mg and tirzepatide 15 mgalso causing the greatest lean mass losses

While the two medications are similar in this way, they differ in others

These cancers are more common in females than males

7 In patients with T2DM, the release of incretin hormones is physiologically insufficient, thereby compromising the ability to adequately secrete insulin and also execute other physiologic processes required to meet the metabolic requirements to maintain normoglycemia