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These agents act through multiple mechanisms, including direct cardioprotection, vasodilation, natriuresis, weight reduction, lipid profile improvement, anti-inflammatory effects, renal protection, reduction in plaque formation, and neurohormonal regulation
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However, phosphatidylinositol 3-kinase (PI3K) rather than PKA activation seems to be the principle signaling mechanism by which the GLP-1r controls -cell growth and apoptosis
