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Lancet 2008;371(9627):183947
The efficacy, safety, and potential of oral glucagon-like peptide-1 (GLP-1) 2025, orforglipron, in oral obesity treatment were demonstrated because, in the ATTAIN-1 Phase 3 study, in 72 weeks, the average weight loss was 12.4 percent and cardiometabolic risk factors were improved (Eli Lilly, 2018)

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Tirzepatide, used in medications like Mounjaro and Zepbound, showed even greater results, where participants in some trials lost up to 22.5% of their body weight

232,233,241,259 (Fig
