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Also available is Foundayo (orforglipron), a newer oral GLP-1 that enables flexible intakefree from specific food or water restrictions

The findings from the SURMOUNT-1 trial, which included individuals with obesity but without diabetes, demonstrated that weekly doses of tirzepatide at 5 mg, 10 mg, and 15 mg led to an average weight loss of 15 %, 19 %, and 21 %, respectively, in contrast to a mere 3 % observed in the placebo group over 72 weeks [24]

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The clinical aspects of the DPP-4 inhibitors, which are now used world-wide for diabetes treatment, will be discussed by Deacon, Ahren and others in other contributors to this Research Topic