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There is consistent evidence from RCTs and real-world studies that SGLT2i use in type 1 diabetes is associated with an increased risk of DKA [14]
In our base case, we assume an 8% peak penetration rate outside the US
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As for Hengruis oral HRS-7535, it indeed shows a noticeable gap in weight loss efficacy compared to the first two, and also has a high incidence of nausea and vomiting
