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Add appetite suppression and rapid weight loss to the mix, and those gaps can become more noticeable

All three amylin products appear to have the potential to challenge tirzepatide on an efficacy/tolerability basis, so it will be interesting to see how Novo Nordisk and Eli Lilly position these products alongside their current GLP-1 offerings
Obesity (Silver Spring) 29(5):829836 Muratori F et al (2022) Efficacy of liraglutide 3.0 mg treatment on weight loss in patients with weight regain after bariatric surgery

Preclinical models show that GLP-1 RAs reduce amyloid- plaque deposition, dampen neuroinflammation, and enhance synaptic plasticity

But, the selective MAPK inhibitors of SB203580, SP600125 and PD98059 can block exendin-4-induced phosphorylation of JNK, ERK1/2 and p38
