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A primary benefit of a GLP-1 agonist is its ability to signal satiety

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Tirzepatide discontinuation data tells a similar story

Other side effects in these trials were nausea in up to 60% of patients, dysesthesia in 8.8 to 20.9%, and heart rhythm changes in 6% versus 3% for placebo

In an ob/ob/ mouse model, 10 weeks of empagliflozin treatment markedly enhanced coronary microvascular function by inhibiting SGLT2 activity, thereby improving cardiac contractility [128]
