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The first randomised controlled trial of semaglutide for alcohol use disorder, published in JAMA Psychiatry in 2025, found that people taking low doses had fewer heavy drinking days, fewer cravings, and reduced alcohol intake compared to placebo

Studies show up to 25-39% of weight lost on GLP-1s can come from lean mass - without intentional resistance training and adequate protein

Target above 1.2g per kg of bodyweight daily, spread across meals not because it's trendy, but because without it, up to 20-25% of the weight lost on a GLP-1 can come from muscle instead of fat

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