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A combined effect that is bigger than just decreasing calories is thought to be at play when looking at the effects of activating the GLP-1 receptor.[ref] In overweight adults aged 45+, a 4-year-long study using semaglutide for weight loss also prevented HbA1c from rising over time, which was seen in the placebo arm

J.HardyN

[DOI] [PMC free article] [PubMed] [Google Scholar] 631.Ban K., Kim K.H., Cho C.K., Sauve M., Diamandis E.P., Backx P.H

Although blood pressure lowering is an established mechanism for reducing MACE, the magnitude seen with GLP-1RAs is likely insufficient to explain the full extent of CV benefit (66)

Wadden TA, Foreyt JP, Foster GD, et al