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2007 Oct;61(10):1777-8 )
It is important to note that there is no definitive scientific consensus that these drugs directly cause pancreatitis, and the absolute risk appears to be low based on clinical trial data
NICE guidance (NG28) recommends individualised HbA1c targets, typically around 48 mmol/mol (6.5%) for most adults with type 2 diabetes, or up to 53 mmol/mol (7.0%) for those at risk of hypoglycaemia or with other individual factors
Tirzepatide is not recommended during pregnancy
Approximately half of the participants had multiple weight-related comorbidities, most commonly hypertension and dyslipidaemia [22]
