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In the SUMMIT trial, patients with HFpEF and obesity were randomized to the long-acting glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist tirzepatide ( n = 364, 200 women) or placebo ( n = 367, 193 women)

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The bigger picture: GLP-1 landscape evolution Orforglipron and tirzepatide exist within a rapidly evolving treatment landscape

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