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Diabetes Obes Metab 23:529 Holst JJ (2019) The incretin system in healthy humans: The role of GIP and GLP-1

Akkermansia muciniphila produces propionate and a protein called P9, both of which induce GLP-1 secretion

It can be found that compared with the Model group, the Low group and High group secreted more insulin after berberine treatment (Figure 1I), and calculated homeostatic model assessment of insulin resistance (HOMA-IR) index according to the following formula: HOMA-IR = FBG (mM) Fasting insulin (mU/L)/22.5 (Figure 1J)

GLP-1RAs cardiovascular advantages have resulted in their preference as second-line treatment for T2DM patients who already have established atherosclerotic cardiovascular disease

Gentle physical activity and adequate sleep can also help