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The general guidance is to increase the dose only when weight loss has plateaued at the current level and side effects are manageable

CNNs Meg Tirrell contributed to this report

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It helps people: eat less without feeling constantly hungry stay fuller longer after meals reduce cravings and emotional eating improve insulin sensitivity stabilize blood sugar maintain a calorie deficit more consistently When the body consistently takes in fewer calories than it burns, it begins using stored fat for energy

Switching from semaglutide to tirzepatide dosing typically involves starting tirzepatide at the initial recommended dose (e.g., 2.5 mg) regardless of the prior semaglutide dose, to assess tolerance and minimize gastrointestinal side effects