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Currently, there is no direct evidence that Ozempic or semaglutide causes cold sores

Additionally, if cold intolerance is accompanied by chest pain, shortness of breath, dizziness, or rapid heart rate , immediate medical attention is warranted to exclude cardiovascular complications

Severe or persistent abdominal pain, repeated vomiting, fainting, allergic symptoms, or signs of low blood sugar warrant prompt medical attention

Diarrhoea is another potential concern

More recently, sodiumglucose cotransporter 2 inhibitors (SGLT2is) have been shown to reduce progression of CKD, CV events, and all-cause mortality and have become an additional first-line therapy (7,8)