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You should contact your GP or seek specialist referral if you are experiencing: Unexplained weight gain or difficulty losing weight despite lifestyle changes Symptoms that may suggest growth hormone deficiency , such as persistent fatigue, reduced muscle mass, increased abdominal fat, or low mood formal biochemical testing is required before any treatment is initiated Poorly controlled blood glucose or a new diagnosis of type 2 diabetes Interest in weight-management medicines , to discuss licensed options available through NHS or regulated private pathways access to weight-management pharmacotherapy on the NHS is typically via specialist weight management services, subject to local eligibility criteria Seek urgent medical attention via NHS 111 or, if necessary, 999 if you experience severe or persistent abdominal pain (which may indicate pancreatitis), signs of a serious allergic reaction, chest pain or palpitations, or symptoms of diabetic ketoacidosis (extreme thirst, frequent urination, confusion, or vomiting)

Employers may also consider setting a higher body mass index (BMI) threshold for coverage eligibility, such as at 35 (class II obesity) or 40 (class III obesity)

[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Adams JM, Pei H, Sandoval DA, Seeley RJ, Chang RB, Liberles SD, et al

Two molecules, two rhythms, two uses

Because of risks found in clinical trials, the drug carries an FDA boxed warning that it could trigger thyroid tumors