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Patients with established cardiovascular disease should receive a pharmacological treatment intensification with an agent that has demonstrated benefit in cardiovascular safety studies: In patients with pre-existing atherosclerotic cardiovascular disease (ASCVD), a GLP-1 receptor agonist, or SGLT-2 inhibitor with characterized cardiovascular safety should be used

The analysis showed that GLP-1s containing tirzepatide (Zepbound, Mounjaro) helped people lose more weight than those containing semaglutide (Ozempic, Wegovy)

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For some, the weight loss and metabolic benefits of GLP-1 RAs might be the primary driver for mood improvement, whereas for others, a traditional antidepressant might be more directly suited to their specific depressive symptoms

For those planning pregnancy after GLP-1 use, our guide covers GLP-1 considerations around pregnancy and breastfeeding