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Allison Whitten Biogen's Alzheimer's tau drug misses its primary endpoint, pushes forward Biogen shared topline results from the Phase 2 CELIA study of diranersen (BIIB080), a tau-targeting antisense oligonucleotide discovered by Ionis Pharmaceuticals and licensed to Biogen in 2019

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This is currently not well understood

Participants had a mean (SD) age of 52.4 (14.5) years, 68.2% were female, 44.2% were non-Hispanic White, 50.7% had T2D, and 48.3% had obesity (BMI 30)