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This suggests that Semaglutide may have broader implications beyond weight management, potentially reducing the risk of heart disease and other obesity-related complications
Similar to the cell subclusters, a key functionally related group of genes differentially expressed across the cell subclusters were related to cell identity and maturity

The receptor responsible for mediating these effects has not yet been conclusively identified

After activation by full agonists such as GLP-1, GLP-1R couples with Gs, activates adenylate cyclase (AC), and causes the accumulation of cAMP