how safe are glp-1 Pharmacological interventions for obesity in patients with inflammatory bowel disease: A systematic review of receptor agonist efficacy and safety The Clinical Application of GLP-1RAs
Description
Both GLP-1 agonists and resmetirom have indirect anti-inflammatory and anti-fibrotic effects through their metabolic action
However, several factors could accelerate a reversal: declining GLP-1 drug prices through manufacturer competition or government negotiation, improved adherence data from newer formulations, long-term outcomes studies demonstrating cardiovascular benefit that changes the cost-benefit analysis, and state legislative mandates requiring obesity treatment coverage
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Metabolites within the gut play a crucial role in mediating interactions between microbiota and the host, contributing to intestinal homeostasis
