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The global prevalence of diabetes continues to rise, with projections indicating a substantial increase in disease burden over the coming decades ( Patients with T2DM and ESRD represent a particularly high-risk population characterized by advanced metabolic dysfunction, a high burden of cardiovascular disease, and extensive polypharmacy ( Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic control by increasing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and inducing weight loss

61,94 These cells are known to actively survey the CNS environment to orchestrate changes to maintain brain homeostasis, meet changing physiological needs, and respond to pathological events by serving as brain immune cells to coordinate innate immune responses

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