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Unfortunately, these medications have modest activity and significant potential for toxicity [44]

Some are lighter and easier to get down, while others are more substantial

Source: 1 Cleveland Clinic GLP-1 Agonists

Insulin resistance as a link between amyloid-beta and tau pathologies in Alzheimers disease

The initial muscle loss seen with GLP-1 RA treatment as well as the ongoing replacement of muscle with fat with treatment cycles involving treatment interruptions can result in unfavorable changes in body composition in patients with obesity that can have profoundly negative repercussions, and can exacerbate obesity-related metabolic and health concerns 14,15,16
