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Pharmacological treatment for obesity works best when supported by sustainable lifestyle changes

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Therefore, the downstream response blocked by MC4R deficiency could affect the anorexigenic effect of the GLP-1analog, but its effect has not been confirmed yet

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Although the benefits of GLP-1 RAs in HF (particularly HFrEF) and CAD remain less definitive, emerging data suggest potential roles in improving PAD and blood pressures, reducing symptoms in HF, and possibly lowering the risk of AF
