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As with other treatments for obesity that resulted in significant weight reduction, the incidence of gallbladder-related events was higher among the participants who received tirzepatide than among those who received placebo. In addition, Jastreboff et al

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"Based on volume alone, the prescribing is not in keeping with the standards of the profession." Investigators in two separate Canadian provinces British Columbia, where the majority of the prescriptions were filled, and Nova Scotia, a province across the country told Insider their investigation is still underway, but so far they're tightening up international sales of the Type 2 diabetes drug, often used off-label for weight loss, and they have suspended Davison's license to practice medicine in Nova Scotia

Leave-one-out refitting indicated that the results were robust to sequentially excluding each study

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