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Cardiovascular and non-cardiovascular safety of dipeptidyl peptidase-4 inhibition: a meta-analysis of randomized controlled cardiovascular outcome trials

Dujic et al., 2017)

3 washes were performed with DMF

Initial reports in animals showed that GLP-1 acutely increases blood pressure (BP) and heart rate (HR) in rats and mice, actions mediated through activation of the autonomic nervous system, including medullary catecholamine neurons, providing input to sympathetic preganglionic neurons (13)

Several mechanisms may potentially contribute to blood pressure effects, including: weight loss (a well-established factor in blood pressure reduction), possible promotion of natriuresis (sodium excretion by the kidneys), and theoretical improvements in endothelial functionthough many of these mechanisms remain hypothetical rather than definitively proven