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Tingling in the hands and feet, dry mouth, and a flat metallic taste with carbonated drinks tend to be most noticeable during this adjustment window

A 2014 study in the Journal of Neuroscience found that activating spinal GLP-1 receptors specifically suppressed pain hypersensitivity via spinal microglia [7]

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While both are weekly, tirzepatide includes an additional hormone mimic (GIP) that some studies suggest may lead to greater weight loss for certain individuals

What is dysesthesia and should I be concerned about it