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Retatrutide may be the preferred option for patients with specific, co-existing metabolic issues, such as significant non-alcoholic fatty liver disease (MASH) , or for those who need to maximize weight loss results

But it also means the medication interacts with neural pathways in ways that single-mechanism drugs do not

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Starting tirzepatide can feel like a breakthrough for weight loss, but a sudden tirzepatide rash or injection-site reaction can knock the wind out of you